Disease-specific B cell epitopes for serum antibodies from patients with severe acute respiratory syndrome (SARS) and serologic detection of SARS antibodies by epitope-based peptide antigens
Identifieur interne : 005576 ( Main/Exploration ); précédent : 005575; suivant : 005577Disease-specific B cell epitopes for serum antibodies from patients with severe acute respiratory syndrome (SARS) and serologic detection of SARS antibodies by epitope-based peptide antigens
Auteurs : I-Ju Liu [Taïwan] ; Po-Ren Hsueh [Taïwan] ; Chin-Tarng Lin [Taïwan] ; Chien-Yu Chiu [Taïwan] ; Chuan-Liang Kao [Taïwan] ; Mei-Ying Liao [Taïwan] ; Han-Chung Wu [Taïwan]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 2004.
Descripteurs français
- KwdFr :
- Alignement de séquences, Animaux, Anticorps antiviraux (immunologie), Anticorps antiviraux (sang), Antigènes viraux (immunologie), Banque de peptides, Cellules Vero, Données de séquences moléculaires, Humains, Lymphocytes B (immunologie), Motifs d'acides aminés (immunologie), Peptides (immunologie), Peptides (isolement et purification), Réaction antigène-anticorps, Spécificité d'espèce, Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (sang), Syndrome respiratoire aigu sévère (étiologie), Séquence d'acides aminés, Virus du SRAS (immunologie), Épitopes (immunologie), Épitopes (isolement et purification).
- MESH :
- immunologie : Anticorps antiviraux, Antigènes viraux, Lymphocytes B, Motifs d'acides aminés, Peptides, Syndrome respiratoire aigu sévère, Virus du SRAS, Épitopes.
- isolement et purification : Peptides, Épitopes.
- sang : Anticorps antiviraux, Syndrome respiratoire aigu sévère.
- étiologie : Syndrome respiratoire aigu sévère.
- Alignement de séquences, Animaux, Banque de peptides, Cellules Vero, Données de séquences moléculaires, Humains, Réaction antigène-anticorps, Spécificité d'espèce, Séquence d'acides aminés.
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Amino Acid Motifs (immunology), Amino Acid Sequence, Animals, Antibodies, Viral (blood), Antibodies, Viral (immunology), Antibody, Antigen, Antigen-Antibody Reactions, Antigenic determinant, Antigens, Viral (immunology), B-Lymphocyte, B-Lymphocytes (immunology), Chlorocebus aethiops, Detection, Epitopes (immunology), Epitopes (isolation & purification), Human, Humans, Microbiology, Molecular Sequence Data, Peptide Library, Peptides, Peptides (immunology), Peptides (isolation & purification), SARS Virus (immunology), Sequence Alignment, Serology, Serum, Severe Acute Respiratory Syndrome (blood), Severe Acute Respiratory Syndrome (etiology), Severe Acute Respiratory Syndrome (immunology), Severe acute respiratory syndrome, Species Specificity, Vero Cells.
- MESH :
- chemical , blood : Antibodies, Viral.
- blood : Severe Acute Respiratory Syndrome.
- etiology : Severe Acute Respiratory Syndrome.
- immunology : Amino Acid Motifs, Antibodies, Viral, Antigens, Viral, B-Lymphocytes, Epitopes, Peptides, SARS Virus, Severe Acute Respiratory Syndrome.
- chemical , isolation & purification : Epitopes, Peptides.
- Amino Acid Sequence, Animals, Antigen-Antibody Reactions, Chlorocebus aethiops, Humans, Molecular Sequence Data, Peptide Library, Sequence Alignment, Species Specificity, Vero Cells.
Abstract
Severe acute respiratory syndrome (SARS) has emerged as a highly contagious, sometimes fatal disease. To find disease-specific B cell epitopes, phage-displayed random peptide libraries were panned on serum immunoglobulin (Ig) G antibodies from patients with SARS. Forty-nine immunopositive phage clones that bound specifically to serum from patients with SARS were selected. These phageborne peptides had 4 consensus motifs, of which 2 corresponded to amino acid sequences reported for SARS-associated coronavirus (SARSCoV). Synthetic peptide binding and competitive-inhibition assays further confirmed that patients with SARS generated antibodies against SARS-CoV. Immunopositive phage clones and epitope-based peptide antigens demonstrated clinical diagnostic potential by reacting with serum from patients with SARS. Antibody-response kinetics were evaluated in 4 patients with SARS, and production of IgM, IgG, and IgA were documented as part of the immune response. In conclusion, B cell epitopes of SARS corresponded to novel coronavirus. Our epitope-based serologic test may be useful in laboratory detection of the virus and in further study of the pathogenesis of SARS.
Url:
- https://api.istex.fr/ark:/67375/HXZ-P5B21G08-N/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109815
DOI: 10.1086/422753
Affiliations:
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<term>Animals</term>
<term>Antibodies, Viral (blood)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Antibody</term>
<term>Antigen</term>
<term>Antigen-Antibody Reactions</term>
<term>Antigenic determinant</term>
<term>Antigens, Viral (immunology)</term>
<term>B-Lymphocyte</term>
<term>B-Lymphocytes (immunology)</term>
<term>Chlorocebus aethiops</term>
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<term>Epitopes (immunology)</term>
<term>Epitopes (isolation & purification)</term>
<term>Human</term>
<term>Humans</term>
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<term>Molecular Sequence Data</term>
<term>Peptide Library</term>
<term>Peptides</term>
<term>Peptides (immunology)</term>
<term>Peptides (isolation & purification)</term>
<term>SARS Virus (immunology)</term>
<term>Sequence Alignment</term>
<term>Serology</term>
<term>Serum</term>
<term>Severe Acute Respiratory Syndrome (blood)</term>
<term>Severe Acute Respiratory Syndrome (etiology)</term>
<term>Severe Acute Respiratory Syndrome (immunology)</term>
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<term>Species Specificity</term>
<term>Vero Cells</term>
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<term>Animaux</term>
<term>Anticorps antiviraux (immunologie)</term>
<term>Anticorps antiviraux (sang)</term>
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<term>Banque de peptides</term>
<term>Cellules Vero</term>
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<term>Peptide Library</term>
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<front><div type="abstract">Severe acute respiratory syndrome (SARS) has emerged as a highly contagious, sometimes fatal disease. To find disease-specific B cell epitopes, phage-displayed random peptide libraries were panned on serum immunoglobulin (Ig) G antibodies from patients with SARS. Forty-nine immunopositive phage clones that bound specifically to serum from patients with SARS were selected. These phageborne peptides had 4 consensus motifs, of which 2 corresponded to amino acid sequences reported for SARS-associated coronavirus (SARSCoV). Synthetic peptide binding and competitive-inhibition assays further confirmed that patients with SARS generated antibodies against SARS-CoV. Immunopositive phage clones and epitope-based peptide antigens demonstrated clinical diagnostic potential by reacting with serum from patients with SARS. Antibody-response kinetics were evaluated in 4 patients with SARS, and production of IgM, IgG, and IgA were documented as part of the immune response. In conclusion, B cell epitopes of SARS corresponded to novel coronavirus. Our epitope-based serologic test may be useful in laboratory detection of the virus and in further study of the pathogenesis of SARS.</div>
</front>
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<affiliations><list><country><li>Taïwan</li>
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<name sortKey="Chiu, Chien Yu" sort="Chiu, Chien Yu" uniqKey="Chiu C" first="Chien-Yu" last="Chiu">Chien-Yu Chiu</name>
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<name sortKey="Kao, Chuan Liang" sort="Kao, Chuan Liang" uniqKey="Kao C" first="Chuan-Liang" last="Kao">Chuan-Liang Kao</name>
<name sortKey="Liao, Mei Ying" sort="Liao, Mei Ying" uniqKey="Liao M" first="Mei-Ying" last="Liao">Mei-Ying Liao</name>
<name sortKey="Lin, Chin Tarng" sort="Lin, Chin Tarng" uniqKey="Lin C" first="Chin-Tarng" last="Lin">Chin-Tarng Lin</name>
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<name sortKey="Wu, Han Chung" sort="Wu, Han Chung" uniqKey="Wu H" first="Han-Chung" last="Wu">Han-Chung Wu</name>
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